The strength of a dermal template.
The simplicity of collagen.
Collagen ECM dressing to treat acute and chronic wounds from Day One.1
Contains 90% native, intact collagen and 10% extracellular matrix components
Broad spectrum MMP reduction2
Advanced care accessible to all clinicians
Cost efficiency through weekly applications3
Why wait to treat chronic wounds? Chronic wounds appear to have a degraded or missing extracellular matrix (ECM).4 Until the
"conservative measures timeframe"5 has been met, advanced therapies such as skin substitutes
were not an option, so clinicians have had to wait.
The importance of an intact ECM
An essential element in living tissue, the extracellular matrix:4
Regulates intercellular communication
Serves as a scaffold to hold tissues together
Provides structural support to help tissue repair
But, degraded ECM delays healing and may lead to the wound becoming chronic.6
Native structure vs. denatured matrix
Processed collagen/ORC dressings contain a denatured matrix structure.
Endoform dermal template retains the structure and function of the native ECM7 to supplement
the patient's degraded matrix.4
A collagen ECM treatment option within your reach
Can be used to treat chronic wounds from Day One
No physician fixation required
Accessible to all healthcare providers across the continuum of care
Plus Endoform dermal template dressings may be reapplied as infrequently as once per week,
reducing cost and inconvenience compared to other collagen dressings that may need reapplication
more than twice as often, per the instructions for use.
Broad-spectrum MMP reduction
Chronic wounds typically show high levels of certain matrix metalloproteinases (MMPs).
These proteases sequentially degrade the native extracellular matrix, delaying wound healing:8
First, collagenases (MMP1 and MMP8) cause the initial breakdown of the vital ECM structure.
Next, gelatinases (MMP2 and MMP9) further degrade the already-damaged ECM fragments into even smaller components.
To reduce excess MMP activity, collagen dressings act as a sacrificial substrate,6 but not all collagen
dressings perform the same.2 In laboratory testing, compared to a leading denatured collagen/ORC
dressing, Endoform dermal template demonstrates improved broad-spectrum MMP activity reduction,
especially against critical collagenases (MMP1 and MMP8).2
Endoform dermal template Provides Broad-Spectrum MMP Reduction Compared to Collagen/ORC2
Why wait for wounds to stall? Treat from Day One with Endoform dermal template, the new collagen ECM dressing.
Proven safety and biocompatibility: Endoform dermal template contains a naturally derived
ovine collagen ECM that is terminally sterilized and may be considered more culturally acceptable
than other animal-derived sources.
Indications for Use:
Partial and full thickness wounds
Chronic vascular ulcers
(donor sites, grafts, post Moh's surgery, post laser surgery, podiatric, and wound dehiscence)
(abrasions, lacerations, first and second degree burns, and skin tears)
HCPCS Codes A6021, A6022 collagen dressing.
Negron L, Lun S, May BC. Ovine forestomach matrix biomaterial is a broad-spectrum inhibitor of matrix metalloproteinases and neutrophil elastase. Int Wound J. 2012 Nov 1.
Endoform Dermal Template Instructions for Use.
International consensus. Acellular matrices for the treatment of wounds. An expert working group review. London: Wounds International, 2010.
Medicare Local Coverage Determination (LCD) criteria require the wound to have been present for a predetermined number of weeks and to have failed to respond to documented conservative measures prior to authorizing reimbursement on more advanced wound therapies such as skin substitutes. Number of weeks varies by region.
Schultz GS, Ladwig G, Wysocki A. Extracellular matrix: review of its roles in acute and chronic wounds. World Wide Wounds. August 2005
Lun S, Irvine SM, Johnson KD, Fisher NJ, Floden EW, Negron L, et al. A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials 2010 Jun;31(16):4517-4529.
Schultz GS, Mast, BA, Molecular Analysis of the Environments of Healing and Chronic Wounds: Cytokines, Proteases, and Growth Factors. Primary Intention. February 1999.
Caution: Federal (USA) law restricts this device to sale by or on the order of a physician (or properly licensed practitioner).